ZIIP Skincare Clinical Hub

Proven performance - measured by objective skin metrics

An 80-participant independent clinical testing programme assessing the four finished-formula serums, conducted over an 8 & 12-week study — measured with validated instrumentation, clinical grading, and baseline-to-Day-56 comparison.

  • 80

    PARTICIPANTS

  • 4

    CLINICAL STUDIES

  • 8 & 12

    WEEKS

  • 20

    SUBJECTS PER SERUM

How We Test

Each serum was given to 20 people to use at home, under the supervision of a dermatologist. Skin was measured at the start and again at the end, and each person's final reading was compared against their own baseline — so every number is a change in the same skin, not a comparison between groups.

The measurements are taken by the following instruments:

  • Corneometer - hydration in the outer layer, by electrical capacitance
  • Tewameter - how much water is escaping through the skin barrier
  • Cutometer - how far skin stretches, and how quickly it returns
  • DermaLab ultrasound - the density of the dermis below the surface
  • Antera 3D, VISIA and C-Cube - imaging systems that map wrinkle volume, redness, pigmentation, pores and surface texture
  • Sebumeter - how much oil the skin is producing

Full Active Evidence Library

Low-Weight Hyaluronic Acid

Significantly improves hydration and skin smoothness — n=20, 0.1% low-weight HA, long-term half-side comparison

+27% overall skin elasticity at 8 weeks — n=12, 0.1% low-weight HA, 8wk twice-daily, Cutometer

−10% maximum skin roughness at 8 weeks, reducing wrinkle depth — n=12, 0.1% low-weight HA, 8wk, skin surface replica

Increases skin hydration after only one application — n=12, 0.1% low-weight HA, single application, Corneometer

AI-Designed 3-in-1 Peptide

−20% sebum at 28 days — n=40, 28d

Up to +19% hydration in 7 days — n=40, 7d

Up to −12% pore size in 14 days — n=40, 14d

Probiotic Ferment Complex

Speeds epidermal regeneration by 2 days vs placebo — n=76 women 30–50yo

−16.5% sebum at 56 days vs placebo — n=76, 56d

−10.7% blemishes at 56 days vs placebo — n=76, 56d

−10.1% pore size at 56 days vs placebo — n=76, 56d

+8% skin smoothness at 28 days vs placebo — n=76, 28d

Engineered 0.2% Retinol

−63.7% cheek wrinkles at 12 weeks (−58.7% by 4 weeks) — n=41, 12 wks, VISIA-CR / F.A.C.E.S. analysis

−38.7% eye-area wrinkles at 12 weeks (−27.9% by 4 weeks) — n=41, 12 wks, VISIA-CR / F.A.C.E.S. analysis

+46% epidermal thickness at 4 weeks (+20% measured in vivo) — n=6, 4 wks, biopsy H&E and confocal imaging

Collagen I and III production upregulated at 4 weeks (1.34× and 1.43× vs control) — n=6, 4 wks, gene expression + procollagen staining

+40% dermal glycosaminoglycans at 24 weeks — n=6, 24 wks, retinol vs vehicle

−53% pigmentation at 8 weeks — n=36, 8 wks

−39% crow's feet wrinkles at 8 weeks — n=36, 8 wks

−53% pigmentation at 8 weeks — n=36, 8 wks

−39% crow's feet wrinkles at 8 weeks — n=36, 8 wks

Cica PDRN

+102% skin elasticity vs base formula — n=21, 4 wks · vs ampoule without CICA PDRN

+81.6% damaged barrier recovery at 2 weeks — n=21, 2 wks

−63.8% redness at 2 weeks — n=21, 2 wks

+38.8% facial lifting at 4 weeks — n=21, 4 wks

−57% pore count at 4 weeks — n=21, 4 wks

Epitensive-EVO

+30.3% instant radiance — n=20, single application

−11% crow's feet wrinkle depth at 28 days — n=20 women 43–58yo, 28d

+6.6% cheek smoothness at 28 days — n=20, 28d

Encapsulated Collagen Peptide

+15% skin elasticity vs placebo at 6 weeks — n=23 women 50–62yo, 6 wks split-face

+12% skin bounce-back at 6 weeks — n=23, 6 wks split-face

Argireline® Amplified

−20% crow's feet wrinkles at 28 days — n=41 women 35–59yo, 28d

−14.7% fine lines at 14 days — n=41, 14d

+13.8% plumpness at 28 days — n=41, 28d

+11.4% smoother skin at 28 days — n=41, 28d

Marine Samphire Bioactive

+25% skin luminosity at 42 days — n=30 women 46–65yo sensitive skin, 42d

−16.5% crow's feet wrinkles at 42 days — n=30, 42d

+16% skin suppleness at 42 days — n=30, 42d

Dendriclear™ Antimicrobial

−82% pustules at 28 days — n=14 with papules, 28d

Up to −77% sebum production at 28 days — n=15 14–40yo acne-prone, 28d

−32% appearance of blackheads / whiteheads at 28 days — n=14, 28d

+27% increased skin microbiome diversity vs placebo at 28 days — n=19 acne-prone, 28d split-face

Bioactive Algae Extract

+51% skin radiance at 14 days — n=10 40–55yo, 14d

−12% blocked pores at 28 days — n=10 18–30yo acne-prone, 28d

−12% redness in 14 days — n=10 40–55yo, 14d

−10% sebum production at 28 days — n=10 18–30yo, 28d

Bio-Identical Ceramide Complex

+57.3% hydration at 5 days — n=89, 5d

+85% barrier strength at 5 days — n=89, 5d

−81% itching at 5 days — n=89, 5d

+38.8% elasticity at 5 days — n=89, 5d

Peeling Complex (AHA/BHA) 3%

Brightens dark spots significantly faster than placebo at 9 days — n=20, 28d

Lectroglaze™

−14.2% area of elongated pores at 28 days — n=161 20–60yo, 28d

+8.8% skin translucency for a glass-skin look at 28 days — n=161, 28d

+18.2% skin hydration at 28 days — n=161, 28d

Gold-Stabilised Vitamin C + Glutathione

After 30 days, free ascorbic acid loses 90% of its potency — this gold-stabilised form retains 94% — Stability at 25±3°C, 60% RH (UV-Vis 291.3 nm)

70% better antioxidant defence vs free Vitamin C — n=10 females 22–57yo, 15-min

40% better antioxidant defence against blue light (400–445 nm) vs free Vitamin C — n=10, 15-min

−18% pigmentation at 28 days — visibly more even tone — n=15 25–45yo, 28d

Multi-Lifting Botanical Complex

>200% primary wrinkle reduction vs placebo at 28 days — n=10 61–65yo, 28d

+381% smoother skin vs placebo cream at 28 days — n=12 49–60yo, 28d

−10.8% instant wrinkle reduction — n=10, 5-min

Brightening Multi-Mineral Complex

+14% skin oxygen availability at 30 minutes — immediate oxygen boost for skin glow — n=22 avg 37yo, 30-min

−7% skin roughness at 28 days — n=23 avg 40yo, 28d

Apple + Pomegranate Exosome Complex

−7% UV spots at 4 weeks — n=10 M&F, 4 wks

Gluconolactone (PHA)

−23% roughness, −14% dullness, −33% dryness — n=22, peeling complex study

Finished-formula clinical evaluation across four pillar serums.

Studies were run by Eurofins Cosmetics & Personal Care in Italy, coordinated by Eurofins Product Testing UK.

Study ref. STUN726AA0102

Download